Mental health is much more than psychiatric and psychological concerns. Mental health encompasses how the brain functions cognitively. One protein found mostly in the brain has an extraordinary impact on brain function.
In 1982, two scientists named Yves-Alain Barde and Hans Thoenen isolated the protein brain-derived neurotrophic factor (BDNF). In the brain, BDNF plays a crucial role in neuronal survival, growth, and differentiation. BDNF is identified as a critical component in learning and memory, influencing neuroplasticity and the formation of new connections between neurons. Researchers found that this protein is very active in the cortex, basal forebrain and hippocampus.
BDNF supports:
Neuroplasticity: BDNF supports the growth and maintenance of neurons and synapses, facilitating the brain’s ability to adapt and change throughout life.
Neurogenesis: BDNF stimulates the generation of new neurons, a process called neurogenesis, in areas like the hippocampus.
Neuroprotection: BDNF can help protect neurons from damage and death, contributing to brain health.
Mood Health: BDNF is often reduced in individuals with persistent low mood and feelings of tension and anxiety.
Learning and memory: BDNF is involved in the formation and consolidation of memories, especially in brain regions like the hippocampus.
Supplements that Support BDNF
IQ200® Kesum (Polygonum minus) is an herb nicknamed “smart weed,” because of its ability to improve cognitive performance as well as supports healthy mood.
IQ200® supplementation has been linked to increased levels of BDNF. One study of women with mild cognitive impairment and who reported moderate stress levels exhibited improvements in BDNF when supplementing with IQ200®.
Another supplement, NeuroActin®, also impacts BDNF. BDNF and the enzyme glycogen synthase kinase 3 (GSK3) are interconnected in various neurological processes, including mood regulation, neuroprotection, and synaptic plasticity.
BDNF plays a role in activating signaling pathways, such as the PI3K/AKT pathway, which can lead to the inactivation of GSK3. GSK3, in turn, influences BDNF-mediated signaling, impacting neuronal survival, neurogenesis, and resilience to injury.
NeuroActin® inhibits GSK3b, increases hippocampal synaptic proteins, protects post-synaptic proteins and neuronal cell loss, and stimulates neurogenesis. The result of this pathway in a human study was reduced changes in Annualized Percentage Brain Volume (36.5%) and Annualized Brain Parenchymal Fraction (75%) compared to placebo after 24 months, as shown by MRI in participants.
Market Opportunities
Here’s a nugget to think about: according to Nutrition Business Journal’s 2024 Condition Specific Report, the brain health market was the third fastest-growing category and is expected to remain in the top three through 2027.
IQ200® is effective for a diverse range of individuals, including those who exercise regularly and use pre-workout supplements, gamers, and seniors seeking cognitive enhancement. Research has demonstrated that IQ200® significantly improves various aspects of mental performance across different demographics.
- For Fitness: Exercise – especially interval aerobics – has been shown in numerous studies to increase endogenous BDNF. IQ200® helps enhance focus and cognitive flexibility, which can be beneficial during intense physical activity. It supports better mental clarity, allowing users to maintain concentration and optimize their training sessions.
- For Gamers: The ingredient aids in improving reaction times and processing speed, which is essential for gaming performance. Enhanced visual memory and reduced negative mood states can create a more enjoyable and compelling gaming experience.
- For Seniors: As with many other systems and cells in the body, BDNF production tends to subside with advancing age. Clinical studies have shown that IQ200® supports cognitive health in older adults, particularly those with mild cognitive impairment. It has been linked to improved visual memory, mood enhancement, and overall cognitive function.
Because of its ability to protect brain structure during aging, NeuroActin® is an effective addition to brain health supplements geared toward active seniors.
When you stop to a moment to marvel at what your brain is doing right now (including involuntary movements governed by your brain) – that is inspiration to formulate with both IQ200® and NeuroActin®. And inspiration is also born in the brain!
