Obesity puts people at increased risk for chronic diseases such as heart disease, type 2 diabetes, high blood pressure, stroke, and some forms of cancer. Obesity-related illnesses result in hundreds of thousands of preventable deaths each year in the United States and billions of dollars in health care costs.
Nonalcoholic fatty liver disease is currently the most common liver disease in the U.S. and worldwide, affecting an estimated 10-24% of the world’s population. In the U.S., the Center for Disease Control reports that currently, approximately one half of the U.S. adult population is overweight (BMI>25) and one quarter of the U.S. adult population is obese (BMI>30). That means, upwards of 29 million Americans possibly have non-alcoholic fatty liver disease. Even more alarming, non-alcoholic fatty liver disease is now occurring among children in the U.S.
A Catabolic state can be characterized as having a high cortisol (a catabolic stress hormone) level and a low testosterone (an anabolic hormone) level. Conversely, in the anabolic state, the body experiences muscle maintenance or growth, normal metabolic rates, and weight loss in the form of loss of fat. The anabolic state can be characterized by relatively low cortisol levels and high testosterone levels.
AMPK plays a central role in regulating healthy glucose and lipid metabolism and energy production. AMPK activation can prevent abdominal fat accumulation, blocks fatty acid synthesis, and augments fatty acid oxidation. Activation of AMPK also leads to the activation of the glucose transporter GLUT1 in all cells, increase glucose availability for energy production and promotes glycolysis.
Reduce Triglycerides and Fatty Liver
In a randomized, multi-center, placebo controlled study, 107 patients with metabolic syndrome with non alcoholic fatty liver disease were given either placebo or 650 mg of Citrus Flavanone-O-Glycosides or placebo twice a day for 120 days.
The Citrus group showed significant reduction of fasting plasma glucose, total cholesterol, LDL cholesterol, triglycerides, and then the increase of HDL cholesterol. Hepatorenal index was significantly reduced by 46%, accompanied by the reduction of hepatic ultrosonographic patterns of steatosis by 99%. This suggests Citrus Flavanone-Glycosides help improve both liver function and inflammation as confirmed by reduction of TNF−α and CRP.
64 subjects (32 men and 32 women) with moderate stress level were randomized to receive 200 mg/day of Eurycoma Longifolia extract or placebo for 4 weeks. At the end of treatment, Eurycoma group showed significant improvements for Tension (−11%), Anger (−12%), and Confusion (−15%) compared to placebo. Stress hormone profile (salivary cortisol and testosterone) was significantly improved by Eurycoma, with reduced cortisol (−16%) and increased testosterone (+37%). Eurycoma is effectively in restoring stress hormone profile and improving psychological mood state, shielding the body from the detrimental effects of “modern” chronic stress, which may include general day-to-day stress, as well as the stress of dieting, sleep deprivation, and exercise training.
HP Ingredients offers custom formulations and private labeling services to manufacturers. HPI’s innovation in formulations is accomplished by combining our trademarked ingredients with other clinically tested, well-researched nutraceuticals.