The juice and albedo of bergamot has a unique profile of flavonoid and glycosides, such as neoeriocitrin, neohesperidin, naringin, rutin, neodesmin, rhoifolin and poncirin. Naringin have been shown to be beneficial in animal models of atherosclerosis, while neoeriocitrin and rutin have been found to exhibit a strong capacity to prevent LDL from oxidation. Importantly, bergamot juice is rich in brutieridine and melitidine with an ability to inhibit HMG-CoA reductase.
Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is characterized by the appearance of nonnative protein aggregates (or protein misfolding) in various tissues. Aging and exposure to environmental stressors can disrupt the proteostasis network, and contribute to the initiation and progression of disease, affecting the capacity of cells to buffer against the accumulation of misfolded and damaged proteins. ProteoActin™ helps support healthy proteostasis network by activating the lysosomal switch and increasing LAMP 1 protein.
ProteoActinTM inhibits NF-Kappa-Beta – the “Master Inflammatory Switch in the Skin”, to help reduce inflammation and redness. ProteoActin™ additionally has direct effect as an antibacterial and anti-parasitic. ProteoActin™ may be useful for controlling rosacea symptoms, for small and general cuts, sores, burns and wounds; safe for diabetics. (For external use only)
ProteoActin™ significantly increased the migration of human keratinocytes HaCat cells, and reduced the wound injury area in in vitro scratch wound healing assay.
HP Ingredients offers custom formulations and private labeling services to manufacturers. HPI’s innovation in formulations is accomplished by combining our trademarked ingredients with other clinically tested, well-researched nutraceuticals.