Adiponectin is a collagen-like protein found in the adipose tissue. Adiponectin stimulates fatty acid oxidation through the activation of AMPK and plays an important role in glucose and lipid metabolism.
Reduce Hunger Hormone
Ghrelin is a hormone produced in the gut, and its main function is to send a signal to your brain to increase appetite when your stomach is empty. It makes you consume more food, take in more calories and store fat. Leptin is a hormone that is produced by your body’s fat cells. It inhibits hunger and regulates energy balance, so your body does not trigger hunger responses when it doesn’t need energy. People who are overweight have very high levels of leptin causing them to eat more.
In a randomized, double-blind placebo-controlled study, Bergamonte® (a key ingredient in CitruSlim®) significantly reduced ghrelin by 6.89% and 14.90% and reduced leptin by 12.30% and 21.36% after consuming 650mg or 1300mg of Bergamonte® extract respectively, for 12 weeks.
In a double-blind randomized study published in Nutrients~2019, 52 obese participants were given either 650mg of BPE-C, 1300mg BPE-C, or placebo for 90 days. BPE-C reduced significantly fasting glucose by 18%, triglycerides by 32%, body weight by 14.8% and BMI by 15.9% in BPE-C high group. This correlated with a significant reduction of circulating hormones balancing caloric intake, including reduction in leptin by 21%, and ghrelin by 15%. Adiponectin, which is typically low in overweight individuals, also increased by 21.76%, confirming the activation of AMPK.
64 subjects (32 men and 32 women) with moderate stress level were randomized to receive 200 mg/day of Eurycoma Longifolia extract or placebo for 4 weeks. At the end of treatment, Eurycoma group showed significant improvements for Tension (−11%), Anger (−12%), and Confusion (−15%) compared to placebo. Stress hormone profile (salivary cortisol and testosterone) was significantly improved by Eurycoma, with reduced cortisol (−16%) and increased testosterone (+37%). Eurycoma is effectively in restoring stress hormone profile and improving psychological mood state, shielding the body from the detrimental effects of “modern” chronic stress, which may include general day-to-day stress, as well as the stress of dieting, sleep deprivation, and exercise training.
At the end of the 6-week trial, the CitruSlim® group had a 90% completion rate, while the placebo group had an 80% completion rate. Suggesting that the program was easy to follow and not overly restrictive. This is much higher compared to other diet programs, such as 50% completion rate for Atkins and Pritikin diet, 65% completion rate for WeightWatchers and Zone diet.
Participants in the CitruSlim® group showed significant body weight loss of an average of 2.7kg. 2.4kg is in body fat loss, suggesting 87% of the total weight loss is body fat loss. On the other hand, participants in the placebo group did not show significant body weight loss (0.78kg) or body fat loss (0.55kg).
CitruSlim® -HD and CitruSlim® -LD showed a significant reduction (p < .001) in BMI of 3.3% and 3.2%, respectively, at the end of the trial (day 112) compared to baseline (day 0). This is compared to the placebo group who showed a 1.59% increase in BMI.
In this study, ghrelin levels in the participants of CitruSlim® groups were increased from day 0 to day 112. This effect could antagonize protein breakdown and promote weight loss in overweight and obese individuals
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