CitruSlim

CitruSlim^® is an innovative nutraceutical ingredient for healthy weight management. CitruSlim^® is a proprietary blend of Citrus flavanone-O-glycosides and Eurypeptides from Eurycoma Longifolia that can promote an anabolic state, reduce cortisol, activate AMPK, and help balance blood glucose levels. CitruSlim^® can promote healthy weight loss by helping dieters maintain high energy levels during weight loss programs, prevent the body from storing fat, reduce appetites, prevent binge eating, and help stop the “yo-yo” diet effect.

Mode of Action

Activate AMP Kinase
The flavonoids in Bergamonte® Citrus bergamia Risso extract have been shown in research to activate AMPK (adenosine monophosphate-activated protein kinase), a pivotal cell enzyme required to orchestrate the burning of fat and sugar. As we age, AMPK activity significantly slows. Declining AMPK levels can cause the accumulation of abdominal fat, cause changes in appetite, body weight, and energy levels. AMPK is known as the body’s “master regulator of energy metabolism.” Studies show that activation of AMPK leads to the activation of the glucose transporter GLUT1 in all cells, increase of glucose availability for energy production, and encouragement of cells to stop storing
fat and to start burning it for energy.

Adiponectin is a collagen-like protein found in the adipose tissue. Adiponectin stimulates fatty acid oxidation through the activation of AMPK and plays an important role in glucose and lipid metabolism.

Reduce Hunger Hormone

Ghrelin is a hormone produced in the gut, and its main function is to send a signal to your brain to increase appetite when your stomach is empty. It makes you consume more food, take in more calories and store fat. Leptin is a hormone that is produced by your body’s fat cells. It inhibits hunger and regulates energy balance, so your body does not trigger hunger responses when it doesn’t need energy. People who are overweight have very high levels of leptin causing them to eat more.

In a randomized, double-blind placebo-controlled study, Bergamonte® (a key ingredient in CitruSlim®) significantly reduced ghrelin by 6.89% and 14.90% and reduced leptin by 12.30% and 21.36% after consuming 650mg or 1300mg of Bergamonte® extract respectively, for 12 weeks.

In a double-blind randomized study published in Nutrients~2019, 52 obese participants were given either 650mg of BPE-C, 1300mg BPE-C, or placebo for 90 days. BPE-C reduced significantly fasting glucose by 18%, triglycerides by 32%, body weight by 14.8% and BMI by 15.9% in BPE-C high group. This correlated with a significant reduction of circulating hormones balancing caloric intake, including reduction in leptin by 21%, and ghrelin by 15%. Adiponectin, which is typically low in overweight individuals, also increased by 21.76%, confirming the activation of AMPK.

Reduce Cortisol – the Stress Hormone
Eurycoma Longifolia contains a group of small peptides referred to as Eurypeptides that are shown in research to activate CYP-17 enzymes and plays essential role in androgen biosynthesis. More particularly, the Eurypeptides help to promote anabolic state by maintaining low normal cortisol and high normal testosterone levels during stressful period. Eurycoma help to increase energy, reduce fatigue, and inhibit cortisol spike during weight loss program, making it easier for dieters to control their appetite and prevent the body from increasing fat storage.

 

64 subjects (32 men and 32 women) with moderate stress level were randomized to receive 200 mg/day of Eurycoma Longifolia extract or placebo for 4 weeks. At the end of treatment, Eurycoma group showed significant improvements for Tension (−11%), Anger (−12%), and Confusion (−15%) compared to placebo. Stress hormone profile (salivary cortisol and testosterone) was significantly improved by Eurycoma, with reduced cortisol (−16%) and increased testosterone (+37%). Eurycoma is effectively in restoring stress hormone profile and improving psychological mood state, shielding the body from the detrimental effects of “modern” chronic stress, which may include general day-to-day stress, as well as the stress of dieting, sleep deprivation, and exercise training.

Efficacy Findings from Clinical Trials for CitruSlim®

50 moderately overweight men and women were recruited to participate in a 6-week program of stress management, nutrition intervention, exercise, and CitruSlim® supplementation. 40 were given 200mg of CitruSlim®, and 10 were given placebo. All subjects followed a moderate calorie-restricted diet based on resting metabolic rate (RMR), plus a moderate exercise program (5 d/wk including aerobic & strength training), and stress management techniques (daily).

At the end of the 6-week trial, the CitruSlim® group had a 90% completion rate, while the placebo group had an 80% completion rate. Suggesting that the program was easy to follow and not overly restrictive. This is much higher compared to other diet programs, such as 50% completion rate for Atkins and Pritikin diet, 65% completion rate for WeightWatchers and Zone diet.

Participants in the CitruSlim® group showed significant body weight loss of an average of 2.7kg. 2.4kg is in body fat loss, suggesting 87% of the total weight loss is body fat loss. On the other hand, participants in the placebo group did not show significant body weight loss (0.78kg) or body fat loss (0.55kg).

The Cortisol Testosterone ratio decreased significantly by 15% for the CitruSlim® group vs. a 7% increase for the placebo group. CitruSlim® promoted an anabolic state by maintaining normal low cortisol levels and normal high testosterone levels. The higher testosterone levels also contributed to higher energy levels and reduced fatigue, leading to a higher completion rate for the weight loss program.

At the end of the 6 week trial, the CitruSlim™ group showed significant reduction of total cholesterol by 17% and LDL by 15% vs. no change for the placebo group.

Efficacy Findings from Clinical Trial (2) for CitruSlim®

In another double-blind, randomized, placebo-controlled study published in Phytotherapy Research 2021, 90 overweight and obese men and women were given either 200mg of CitruSlim®, 400mg of CitruSlim®, or placebo, 3 times daily before meals (breakfast, lunch & dinner) for 16 weeks. Participants were advised to follow a diet plan that consists of 1500-1800 kcal/day. Participants were allowed a cheat day once a week. Participants did not engage in any exercise due to Covid-19 lockdown & restrictions.

CitruSlim® -HD and CitruSlim® -LD showed a significant reduction (p < .001) in BMI of 3.3% and 3.2%, respectively, at the end of the trial (day 112) compared to baseline (day 0). This is compared to the placebo group who showed a 1.59% increase in BMI.

In this study, ghrelin levels in the participants of CitruSlim® groups were increased from day 0 to day 112. This effect could antagonize protein breakdown and promote weight loss in overweight and obese individuals