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Consumers want to enjoy active lifestyles as they get older – more so than ever because Baby Boomers and Generation X today still feel very youthful, and this is only going to increase with younger adults as they get older.


Cardiometabolic health is an anchor to lively well-being in older years, and young adults today can start ensuring they are cardiometabolically fit by taking a simple dietary supplement containing Bergamonte bergamot-derived polyphenolic fractions (BPF).


International Guidelines in Cardiovascular Prevention Strategies indicate that the target level of serum low-density lipoprotein in high-risk individuals is under 70 mg/dl and that levels in the range 70-100 mg/dl contribute in maintaining low cardiometabolic risk in metabolic syndrome (MetS).


Conversely, the Guidelines also clarified that a reduction of serum triglycerides combined with reduction of low-density lipoproteins (bad cholesterol) is required to further attenuate the risk of severe cardiac illness from atherothrombosis. Also, elevated good cholesterol (high-density lipoprotein) is a tandem goal to support cardiovascular protection in individuals, especially in those who have MetS.


BPF expert Dr. Vincenzo Mollace, Dean and Director of the School of Pharmacy and Nutraceuticals at the University of Magna Graecia of Catanzaro, Italy, and Professor of Pharmacology at the University of Rome added, “Finally, reduction of oxidative stress and subsequent inflammation of vascular wall and attenuated insulin-resistance are considered the remaining ‘five fingers’ that antagonize detrimental vascular responses occurring in people with MetS.”


Several natural products have been widely used in the last decades to protect against development of high cholesterol and triglycerides that characterize MetS.


Red Yeast Rice is an extract obtained from fermented rice that is produced using specific species of mold, Monascus ruber or Monascus purpureus. The extract, used alone or in combination with other nutraceuticals,  contains monacolin K, an analogue of lovastatin — the same active ingredient found in lovastatin-containing medications. Its effect leads to weak reduction of cLDL. Very little effects have been described on triglyceride and cHDL and on oxidative stress. On the other hand, statins enhance insulin resistance. Recent warning has been raised by the European Food Safety Authority (EFSA) concerning the safety profile of current dosage  of Red Yeast Rice (10 mg of monacolin K), due to its identical profile of lovastatin.


Berberine is derived from Berberis vulgaris root extract. The principal activities have been found in counteracting insulin-resistance, mostly via enhanced glucose absorption into skeletal muscle. In addition, berberine seems to reduce triglycerides and to produce a small improvement of cHDL. Further, inconsistent antioxidant properties have been found with berberine.


Policosanols represent a mixture of long-chain alcohols extracted from plant waxes with small lipid-lowering activity. The general perception is that policosanol consumption is safe and well tolerated and is effective at lowering the blood cholesterol with raising HDL. However, no significant effects have been found neither in reducing triglycerides and insulin resistance nor in counteracting vascular oxidative stress.


Oleuropein and polyphenols are derived from Olea europea leaf extracts. This extract, in particular, has been used to protect skin, vessels and the liver from impairment from elevated generation of free radical species. Furthermore, Olea europea derivatives produce reduction of serum lipids and insulin resistance. All these effects, however, are smaller than those exerted by BPF consumption.


The superior choice

Bergamot Polyphenolic Fraction (BPF) as Bergamonte®  is superior to all of the above, and is safe for long-term use with no side effects or compromises with any medications. Research shows that BPF exerts stronger and more desirable cardiometabolic-protective performance compared to other natural products.


BPF contains the highest concentration of polyphenols among different citrus species and contains selected glycosylated polyphenols, such as bruteridine and melitidine, which have been found able to inhibit HMGCoA reductase (an enzyme that processes cholesterol) in a manner similar to that of statins – and without side effects. The vascular protection exhibited by BPF is caused by a powerful enhancement of nitric oxide-mediated vasodilatation. This occurs as a consequence of powerful inhibition of oxygen free radical species generation.


For more information about how Bergamonte® BPF works, please visit





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