The juice and albedo of bergamot has a unique profile of flavonoid and glycosides, such as neoeriocitrin, neohesperidin, naringin, rutin, neodesmin, rhoifolin and poncirin. Naringin have been shown to be beneficial in animal models of atherosclerosis, while neoeriocitrin and rutin have been found to exhibit a strong capacity to prevent LDL from oxidation. Importantly, bergamot juice is rich in brutieridine and melitidine with an ability to inhibit HMG-CoA reductase.
These flavonoids are clinically proven to help maintain healthy cholesterol levels†, healthy blood glucose level, increase HDL-cholesterol, and promoting healthy weight management.
Citrus Bergamot contains melitidin and brutieridin which are absent in C. Aurantium. Research has shown that these compounds significantly support healthy total cholesterol LDL, triglycerides and blood glucose levels, while increasing HDL .
Melitidine and Brutieridin In Bergamonte® Bergamot Polyphenolic Extract…
A research article published in the Journal of Natural Products 2009 showed that bergamot juice contained novel compounds with statin-like properties, having the
3-hydroxy3-methylglutaric acid (HMG) bound to the naringin (melitidin) and neohesperidin (brutieridin).
These novel compounds interfere with the natural synthesis of the cholesterol pathway
in the human body: the HMG-CoA substrate interferes with the synthesis of the mevalonate acid, blocking the cholesterol production.
Superior Full-Spectrum Antioxidant ORAC Potency
Inhibiting Phosphodiesterases (PDEs)
Bergamot flavonoids mediate their beneficial effects on lipid and glucose homeostasis by PDE4 and PDE3B modulation. PDE4 plays a critical role in cAMP (cyclic adenosine monophosphate), which regulates energy metabolism, AMPK, triglyceride hydrolysis, and glucose metabolism. PDE3B is crucial for triglyceride and cholesterol
metabolism, as well as glucose homeostasis. Dysregulation of PDE3B can cause development of fatty liver, common in metabolic syndrome and type-2 diabetes patients.
Flavonoids in Bergamonte® activate AMPK and stimulate glucose uptake. AMPK plays a central role in regulating healthy glucose, and lipid metabolism and energy production. AMPK activation can prevent abdominal fat accumulation, regulate glucose tolerance, normalize liver markers, and reduce oxidative stress and inflammation in the liver and heart. Bergamot flavonoids activate the glucose transporter GLUT1 in all cells and upregulation and translocation
GLUT4 to the cell membrane in muscle cells.
Fitoterapia 82 (Nov 2011) 309–316
237 patients with hyperlipemia, hypercholesterolemic (HC, cLDL, low cHDL), mixed dyslipidemic (HC and TG), or metabolic syndrome (HC, HT, and HG) were taking either placebo, 500mg, 1000mg.
International Journal of Cardiology, 2013
In this open-label, parallel group, placebo-controlled study, 77 patients were randomly assigned either placebo, Rosuvastatin, Bergamot Polyphenolic Fraction or combination of Bergamot Polyphenolic Fraction with Rosuvastatin for 30 days.
Advances in Biological Chemistry, 2014, 4, 129-137
107 patients with metabolic syndrome and non fatty liver disease were given either placebo or 650 mg of Bergamot Polyphenolic Fraction twice a day for 120 days. Bergamot Polyphenolic Fraction group showed significant reduction in fasting plasma glucose, rotal cholesterol, LDL cholesterol, triglycerides, and increase of HDL cholesterol. Bergamot Polyphenolic Fraction decrease IDL particles by 51%, increase large LDL by 38%, decrease small LDL by 35%, and 20% increase of total HDL particles. Hepatorenal index was significantly reduced by 46%, accompanied by reduction of hepatic ultrosonographic pattern of steatosis by 99%. This suggests Bergamot Polyphenolic Fraction improves both liver function and inflammation as confirmed by reduction of TNF-α and CRP.
HP Ingredients offers custom formulations and private labeling services to manufacturers. HPI’s innovation in formulations is accomplished by combining our trademarked ingredients with other clinically tested, well-researched nutraceuticals.