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LJ100 Human Clinical Study

WATER – SOLUBLE EXTRACT OF LJ100 ® AS A POTENTIAL NATURAL ENERGIZER FOR HEALTHY AGING MEN
M.I.M. TAMBI, S. OTHMAN AND J.M. SAAD
SHIQ results showed 62% of the cases having an increased or maximum score. Breakdown of the results showed increase in sexual desire and success in the attempts at sexual intercourse while on treatment and related well with the PADAM score’s results showing improvement in sexual attempts and desire.  PADAM score demonstrated that 82% of the cases showed a decrease in total score. The breakdown included: 91% improvement of sexual component, 73% improvement in the physical component, and 82% improvement of the psychological component. The Vasomotor score showed improvement in 52% of the subjects. Analysis of DHEA showed gradual increase in the level from 26% after 1 week to 47% after 3 weeks. This suggests that the extract may influence the DHEA production, which would in turn subsequently be aromatized to testosterone. SHBG analysis showed that levels were reduced in 36% of the cases after one week. The reduction went up to 66% after 3 weeks. This suggests that the extract could have an effect on the production of SHBG. Consequently, when SHBG level declines, the Free Testosterone Index (FTI) goes up. FTI analysis showed an escalation of 39% of subjects after 1 week and 73% after 3 weeks.

 

THE ANABOLIC EFFECTS OF LJ100 ®     Sareena Hanim Hamzah & Ashril Yusof
Fat free mass of the group supplemented with LJ100 Eurycoma water soluble extract showed a significant increment of approximately 2.1 kg. There were no significant changes in fat free mass in placebo. Body fat percentage were significantly decreased in treatment and placebo. However, a greater decrement was shown in treatment compared to placebo i.e. 9.14% and 6.57% respectively. The 1 RM test muscle strength test showed an increase in gross muscle power in both groups. The treatment group showed a greater increment in strength compared to placebo i.e. 6.78% and 2.77% respectively. The mean arm circumference in treatment group increased significantly by 1.8 cm following the supplementation while no significant changes observed in placebo group. The mean sEMG reading of the treatment and placebo showed a significant decrement in values after going through the exercise program. However, the treatment group showed 2.92% higher reduction in electrical activity of the muscle measured at the end of the experiment period compared to placebo (25.70% and 22.78% respectively). During and after the administration of Eurycoma, no adverse effects were noted within the treatment group.

 

LJ100 ®  Saliva Testosterone Test

• Saliva Testosterone Test of 9 Individuals 26-52 years of Age
• ¢ Dosage 2x2(50mg/capsules) morning & evening for 10 days
• ¢ Normal range for athlete 800 = 150ng/dl of blood

Volunteer	age	pre treatment ng/dl blood	after treatment ng/dl blood Increase	%
1	26	860 = 30	1,650 = 50	91.86%
2	28	580 = 30	985 = 35	69.83%
3	35	875 = 40	1, 576 = 60	80.11%
4	24	950 = 45	2,210 = 55	132.63%
5	29	755 = 30	1,345 = 35	78.15%
6	48	650 = 20	875 = 30	34.62%
7	52	450 = 25	765 = 35	70.00%
8	50	585 = 25	875 = 35	49.57%
9	42	350 = 30	480 = 35	37.14%

Data – preliminary data - more work to be carried out

Volunteers 1-5 are athletes - data are an average of 3 different studies at different times

Volunteers 6-9 do not exercise on a regular basis

2005 Human Clinical
20 male volunteers of various health conditions from the ages of 38 to 58 were randomly given either 200,400,600 mg of LJ100 (22% Bioactive Eurypeptides) or placebo for 2 months. The SHIM (Sexual Health Inventory for Male) scores were elevated to upper normal level showing improvement in sexual desire and performance for majority of the volunteers. The Aging Male Score (AMS) were lowered showing improvement in sexual, physical, psychology, and vasomotor domain for majority of the volunteers. Testosterone and DHEAS levels showed high normal levels when compared to baseline and is consistent with the excellent QOL (Quality of Life) score. LJ100 modulates the production of DHEAS, which would in turn be aromatized to testosterone. Bioavailable testosterone is needed to maintain wellness and enhance libido.

Full blood examinations showed normal limits even at 600mg dosage for all tests. LJ100 does not interfere with the platelets or hemoglobin and does not have any toxicity to the RBC. The liver function test showed no liver toxicity even at high doses of LJ100 . Renal function test showed that LJ100 has no harmful effect on the renal system even for men whose renal function is affected (as seen in the diabetics). Some volunteers even showed improved or normal levels of uric acid at end of trials. Tumor markers are sensitive indicators of cellular stress. AFP( Alpha Fetal Protein) identifies testicular cancer; PSA ( Prostate Specific Antigen) is used to detect prostate cancer. All tumor markers were within normal levels even at 600mg dosage of LJ100 .

The Lipid studies showed increment of high-density lipoprotein (HDL Cholesterol –good cholesterol) levels. Elevations of HDL are normally associated with a lower risk of heart attack.

Volunteers who were diabetic, showed significant effect on lowering the blood glucose levels. LJ100 does not exert hypoglycemic effects but may have influence on the cellular uptake of glucose.

The cortisol levels were in the higher normal level for the LJ100 group as opposed to the placebo group. T

High thyroxin indicates high BMR (Basal Body Metabolism Rate). Majority of volunteers on LJ100 have high normal level of thyroxine compared to the placebo group. This mean slight higher metabolism rate which can be translated to better weight management. Volunteers taking LJ100 have high normal level of IGF-1 at end of trials. Some with low IGF-1 level was increased to normal level after 1 week. Placebo group is showing no change in the IGF-1 levels. This study suggests that LJ100 has a secretagogue effect on growth hormone and modulates the release of IGF-1; in turn, making it a great anti-aging supplement.

Effect of LJ100 on Anabolic Balance During Endurance Exercise 

• Talbott S, Talbott J, Negrete J, Jones M, Nichols M, and Roza J.  
• SupplementWatch, Inc. Draper, UT & Source One Global Partners,  Chicago,  IL  
• Published:  Journal of International Society of Sport Medicine 3 (1): S32  2006

Eurycoma Longifolia, commonly known as "Tongkat Ali" or "Longjack", is often touted as a testosterone "booster" and marketed to athletes as a training aid and performance enhancer. Rodent studies have shown oral delivery of Eurycoma extract to improve sexual performance and increase serum testosterone levels. Open-label human trials have suggested that Eurycoma extract may help prevent age-associated androgen defieciency, improve sexual function, and increase psychological parameters such as mood, ebergy, and sense of well-being. The purpose of this study was to determine the effects of Eurycoma Longiflia on testosterone and cortisol levels during intense endurance exercise.

Methods
We used a freeze dried extract of Eurycoma Longifolia (E) standardized to 22% EuryPeptides and 40% Glycosaponins. Male subjects (N=30) were recruited from a 24-hour mountain biking event and asked to provide a saliva sample before and after each lap for measurement of cortisol and testosterone by enzyme immunoassay (Salimetrics, State College, PA.) Subjects completed 4 laps (14.91 miles / lap) and provided 8 saliva samples over a 24 hour period. Subjects consumed 100mg of E (N = 15) or a look-alike placebo (P, N = 15) approximately 30 minutes prior to exercise.

Results

Cortisol levels were 32.3% lower in E compared to P (0.552+0.665 versus 0.816+0.775 ug/dL, P < 0.05). Testosterone levels were 16.4% higher in E compared to P (86.72+40.90 versus 72.47+33.77 pg/mL, P < 0.05).

Conclusions
These results suggest that Eurycoma Longifolia  extract may help to maintain normal levels of cortisol (low) and testosterone (high) and thus promote an overall "anabolic" hormonal state (versus a "catabolic" state characterized by elevated cortisol and suppressed testosterone) during intense endurance exercise.