Obesity, diabetes, and metabolic
syndrome are reaching epidemic proportions in the United States and
around the world. Today, more than 65 percent of adults in the United
States are overweight or obese. Poor nutrition and physical inactivity
account for some predicted 300,000 premature deaths in the United States
Obesity puts people at increased risk
for chronic diseases such as heart disease, type 2 diabetes, high blood
pressure, stroke, and some forms of cancer. Obesity-related illnesses
result in hundreds of thousands of preventable deaths each year in the
United States and billions of dollars in health care costs.
Fatty liver is a condition wherein
large vacuoles of triglyceride fat accumulates in liver cells via the
process of steatosis. Steatosis is associated with abnormalities in
fatty acid metabolism and lipoprotein metabolism, the accumulation of
adipose fat tissue, possible imbalances in glucose, accompanied by the
progressive inflammation of the liver (hepatitis). Fatty liver occurs
commonly worldwide in individuals with excessive alcohol intake and
individuals that are obese.
Nonalcoholic fatty liver disease is
currently the most common liver disease in the U.S. and worldwide,
affecting an estimated 10-24% of the world's population. In the U.S.,
the Center for Disease Control reports that currently, approximately one
half of the U.S. adult population is overweight (BMI>25) and one quarter
of the U.S. adult population is obese (BMI>30). That means, upwards of
29 million Americans possibly have non-alcoholic fatty liver disease.
Even more alarming, non-alcoholic fatty liver disease is now occurring
among children in the U.S.
Cortisol – the
Cortisol is a critical hormone with
many functions in the body. Cortisol metabolizes fat and carbohydrates
into energy, helping to maintain blood sugar levels, and blood pressure.
Excess cortisol secreted during times of physical or psychological
stress promotes weight gain around the abdominal area. This fat deposit
has been referred to as "toxic fat". Science has demonstrated a clear
link between abdominal adipose tissue and metabolic syndrome,
cardiovascular disease and insulin imbalance.
Catabolism is part of metabolism that breaks down molecules
into smaller units to generate energy and simultaneously takes measures
to conserve energy. Stress, such as during weight loss program, can put
the body into the catabolic state, in which the body can experience
reduced metabolic rate, reduced calorie expenditure, lower energy
levels, which result in binge eating because of perceive hunger, and
weight gain in the form of fat.
A Catabolic state can be
characterized as having a high cortisol (a catabolic stress hormone)
level and a low testosterone (an anabolic hormone) level. Conversely, in
the anabolic state, the body experiences muscle maintenance or growth,
normal metabolic rates, and weight loss in the form of loss of fat. The
anabolic state can be characterized by relatively low cortisol levels
and high testosterone levels.
CitruSlim™ is an innovative nutraceutical ingredient for
healthy weight management. CitruSlim™ is a proprietary blend of Citrus
flavanone-O-glycosides and Eurypeptides from Eurycoma Longifolia that
can promote an anabolic state, reduce cortisol, activate AMPK, reduce
triglycerides, and help balance blood glucose levels. CitruSlim™ can
promote healthy weight loss by helping dieters maintain high energy
levels during weight loss programs, prevent the body from storing fat,
reduce appetites, prevent binge eating, and help stop the “yo-yo” diet
Citrus fruits are well known for
providing ample amounts of vitamin C and bioflavanones that have many
Major flavanones and flavones found in citrus fruits are eriocitrin,
neoeriocitrin, narirutin, naringin, hesperidin, neohesperidin, poncirin,
rutin, diosmin, and rhoifolin. These flavanones can help to activate
AMPK, reduce triglycerides, reduce adipose fat, and maintain healthy
cholesterol and blood sugar levels, and healthy weight management.
Eurycoma longifolia is a powerful adaptogen and is used as a
traditional anti-aging remedy to help older individuals adapt to the
reduced energy, mood, and libido that often comes with age. Eurycoma
contains a group of small peptides referred to as eurypeptides that are
known to have effects in increasing energy levels and enhance
testosterone in both men and women. Eurypeptides additionally help to
increase muscle size and strength, improve overall well-being,
accelerate recovery from exercise, enhance weight loss, reduce cortisol
level, and reduce symptoms of fatigue.
Mode of Action...
Activate AMP Kinase
Naringin, rutin, and neoericitrin found in Citrus Flavanone-Oglycosides
have been shown in research to activate AMPK
(adenosine monophosphate-activated protein kinase), along with related
fat burning gene signals, thus preventing the build up of fat in liver
cells. AMPK is a pivotal cell enzyme required to orchestrate the burning
of fat and sugar.
AMPK plays a central role in
regulating healthy glucose and lipid metabolism and energy production.
AMPK activation can prevent abdominal fat accumulation, blocks fatty
acid synthesis, and augments fatty acid oxidation. Activation of AMPK
also leads to the activation of the glucose transporter GLUT1 in all
cells, increase glucose availability for energy production and promotes
Reduce Triglycerides and Fatty
In a randomized,
multi-center, placebo controlled study, 107 patients with metabolic
syndrome with non alcoholic fatty liver disease were given either
placebo or 650 mg of Citrus Flavanone-O-Glycosides or placebo twice a
day for 120 days.
The Citrus group showed significant
reduction of fasting plasma glucose, total cholesterol, LDL cholesterol,
triglycerides, and then the increase of HDL cholesterol. Hepatorenal
index was significantly reduced by 46%, accompanied by the reduction of
hepatic ultrosonographic patterns of steatosis by 99%. This suggests
Citrus Flavanone-Glycosides help improve both liver function and
inflammation as confirmed by reduction of TNF−α and CRP.
Reduce Cortisol – the Stress
Eurycoma Longifolia contains a group of small peptides referred to as
Eurypeptides that are shown in research to activate CYP-17 enzymes and
plays essential role in androgen biosynthesis. More particularly, the
Eurypeptides help to promote anabolic state by maintaining low normal
cortisol and high normal testosterone levels during stressful period.
Eurycoma help to increase energy, reduce fatigue, and inhibit cortisol
spike during weight loss program, making it easier for dieters to
control their appetite and prevent the body from increasing fat storage.
64 subjects (32 men and 32 women)
with moderate stress level were randomized to receive 200 mg/day of
Eurycoma Longifolia extract or placebo for 4 weeks. At the end of
treatment, Eurycoma group showed significant improvements for Tension
(−11%), Anger (−12%), and Confusion (−15%) compared to placebo. Stress
hormone profile (salivary cortisol and testosterone) was significantly
improved by Eurycoma, with reduced cortisol (−16%) and increased
testosterone (+37%). Eurycoma is effectively in restoring stress hormone
profile and improving psychological mood state, shielding the body from
the detrimental effects of “modern” chronic stress, which may include
general day-to-day stress, as well as the stress of dieting, sleep
deprivation, and exercise training.
from Clinical Trials for CitruSlim™
50 moderately overweight men and
women were recruited to participate in a 6-week program of stress
management, nutrition intervention, exercise, and CitruSlim™
supplementation. 40 were given 200mg of CitruSlim™, and 10 were given
placebo. All subjects followed a moderate calorie-restricted diet based
on resting metabolic rate (RMR), plus a moderate exercise program (5
d/wk including aerobic & strength training), and stress management
techniques (daily). At the end of the 6 weeks trial, the CitruSlim™
group had a 95% completion rate, while the placebo group had an 80%
completion rate. Suggesting that the program was easy to follow and not
overly restrictive. This is much higher compare to other diet programs,
such as 50% completion rate for Atkins and Pritikin diet, 65% completion
rate for weight watcher and Zone diet. Participants in the CitruSlimTM
Group showed significant body weight loss of an average of 2.7kg. 2.4kg
is in body fat loss, suggesting 87% of the total weight loss is body fat
loss. On the other hand, participants in the placebo group do not show
significant body weight loss (0.78kg) or body fat loss (0.55kg).
The Cortisol Testosterone ratio
decreased significantly by 15% for the CitruSlim™ group vs. a 7%
increase for the placebo group. CitruSlim™ promotes an anabolic
state by maintaining normal low cortisol levels and normal high
testosterone levels. The higher testosterone levels also contribute to
higher energy levels and reduced fatigue, leading to a higher completion
rate for the weight loss program.
At the end of the 6 week trial, the
CitruSlim™ group showed significant reduction of total
cholesterol by 17% and LDL by 15% vs. no change for the placebo group.
For more information on CitruSlim
“These statements have
not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent any disease”